A Multifactorial Signature of DNA Sequence and Polycomb Binding Predicts Aberrant CpG Island Methylation
نویسندگان
چکیده
منابع مشابه
Predicting aberrant CpG island methylation.
Epigenetic silencing associated with aberrant methylation of promoter region CpG islands is one mechanism leading to loss of tumor suppressor function in human cancer. Profiling of CpG island methylation indicates that some genes are more frequently methylated than others, and that each tumor type is associated with a unique set of methylated genes. However, little is known about why certain ge...
متن کاملUse of DNA from human stools to detect aberrant CpG island methylation of genes implicated in colorectal cancer.
Hypermethylation of cytosine residues in the CpG islands of tumor suppressor genes is a key mechanism of colorectal carcinogenesis. Detection and quantification of CpG island methylation in human DNA isolated from stools might provide a novel strategy for the detection and investigation of colorectal neoplasia. To explore the feasibility of this approach, colorectal biopsies and fecal samples w...
متن کاملMETHYLATION OF ThE ANDROGEN RECEPTOR CPG ISLAND
Survivinis a memberofthe inhibitor ofapoptosis protein (IAP)family. WeInvestigated the antiapoptotic mechanism ofSurvivin, as well as its expressionIn 60 human tumor cell lines used for the National Cancer lontitute's anticancer drag screening program, In cotransfection experhnents, cell deathInduced by Bax or Faa (CD 95) was partially inhibited (mean ±SD,65%±8%)bySurv...
متن کاملCpG Island Methylation in Human Lymphocytes Is Highly Correlated with DNA Sequence, Repeats, and Predicted DNA Structure
CpG island methylation plays an important role in epigenetic gene control during mammalian development and is frequently altered in disease situations such as cancer. The majority of CpG islands is normally unmethylated, but a sizeable fraction is prone to become methylated in various cell types and pathological situations. The goal of this study is to show that a computational epigenetics appr...
متن کاملAberrant methylation of the Cyclooxygenase 2 CpG island in colorectal tumors.
Cyclooxygenases (COXs) are key enzymes that convert arachidonic acid to prostaglandins. Overexpression of one of the COX isozymes, COX2, has been shown to play an important role in colorectal cancer progression. Recently, however, low expression of COX2 has been reported in a subset of colorectal and gastric cancers. Aberrant CpG island methylation and associated transcriptional silencing are c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer Research
سال: 2008
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-08-3274